CRP appears to be a good screening tool for sepsis however its low sensitivity is a drawback.
These markers also bore a significant association with mortality in both cases and controls (p-Value <0.05).Ĭonclusions: Haematological parameters are poor screening tools for neonatal sepsis however they have a definite role as prognostic indicators. For neutropenia and thrombocytopenia these values were 16%, 81%, 34% and 61% and 41%, 71%, 42% and 70%, respectively. Sensitivity, specificity, negative and positive predictive values for leukopenia were 22%, 68%, 29% and 59%, respectively.
CRP had sensitivity, specificity, negative and positive predictive values of 67%, 19%, 27% and 57%. Results: 120 neonates had confirmed sepsis and 76 were in the control group. A p-value <0.05 was taken as significant. Comparisons were made by chi-square test and Fischer’s exact test. Statistical analysis used was Graphpad Instat statistical software was used for analysis. Relationship of these markers with neonatal mortality was also assessed. CBC and CRP were taken from both groups sensitivity, specificity, negative and positive predictive value of leucopenia, neutropenia and thrombocytopenia were assessed. Neonates with confirmed sepsis were allotted to cases group and others to control group. All patients visiting our hospital with non-specific symptoms and signs suggestive of sepsis were admitted and evaluated. Methods: A prospective observational study was conducted in a level-3 NICU in north India in 2013. This study was designed to assess role of CRP, leukopenia, neutropenia and thrombocytopenia in neonatal sepsis in this changing era. Septic screen, Bactec/BactAlert, Neonatal sepsis Abstractīackground: Emergence of newer culture methods and other diagnostic aids for neonatal sepsis makes evaluation of known sepsis markers imperative to define their changing role. Department of Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K, Indiaĭepartment of Anesthesiology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K, India
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